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1

Efficient Synthesis and Biological Evaluation of 5′-GalNAc Conjugated Antisense Oligonucleotides

Østergaard, Michael E., Yu, Jinghua, Kinberger, Garth A., Wan, W. Brad, Migawa, Michael T., Vasquez, Guillermo, Schmidt, Karsten, Gaus, Hans J., Murray, Heather M., Low, Audrey, Swayze, Eric E., Praka

Journal:

Bioconjugate Chemistry

Year:

2015

Language:

english

File:

PDF, 1.33 MB

english, 2015

2

Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice

Shemesh, Colby S., Yu, Rosie Z., Gaus, Hans J., Seth, Punit P., Swayze, Eric E., Bennett, Frank C., Geary, Richard S., Henry, Scott P., Wang, Yanfeng

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2016

Language:

english

File:

PDF, 806 KB

english, 2016

3

Single-Stranded siRNAs Activate RNAi in Animals

Lima, Walt F., Prakash, Thazha P., Murray, Heather M., Kinberger, Garth A., Li, Wenyu, Chappell, Alfred E., Li, Cheryl S., Murray, Susan F., Gaus, Hans, Seth, Punit P., Swayze, Eric E., Crooke, Stanle

Journal:

Year:

2012

Language:

english

File:

PDF, 1.64 MB

english, 2012

4

Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′ O -Methoxyethyl and 2′,4′-Constrained 2′ O -Ethyl Nucleic Acid Analogues

Seth, Punit P., Vasquez, Guillermo, Allerson, Charles A., Berdeja, Andres, Gaus, Hans, Kinberger, Garth A., Prakash, Thazha P., Migawa, Michael T., Bhat, Balkrishen, Swayze, Eric E.

Journal:

Journal of Organic Chemistry

Year:

2010

Language:

english

File:

PDF, 1.13 MB

english, 2010

5

Selective Frontoinsular von Economo Neuron and Fork Cell Loss in Early Behavioral Variant Frontotemporal Dementia

Kim, Eun-Joo, Sidhu, Manu, Gaus, Stephanie E., Huang, Eric J., Hof, Patrick R., Miller, Bruce L., DeArmond, Stephen J., Seeley, William W.

Journal:

Cerebral Cortex

Year:

2016

Language:

english

File:

PDF, 129 KB

english, 2016

6

Using citizen science to bridge taxonomic discovery with education and outreach

von Konrat, Matt, Campbell, Thomas, Carter, Ben, Greif, Matthew, Bryson, Mike, Larraín, Juan, Trouille, Laura, Cohen, Steve, Gaus, Eve, Qazi, Ayesha, Ribbens, Eric, Livshultz, Tatyana, Walker, Taylor

Journal:

Applications in Plant Sciences

Year:

2018

Language:

english

File:

PDF, 1.13 MB

english, 2018

7

What does the yield curve imply about investor expectations?

Gaus, Eric, Sinha, Arunima

Journal:

Journal of Macroeconomics

Year:

2018

Language:

english

File:

PDF, 1.39 MB

english, 2018

8

Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay

Gaus, Hans J, Gupta, Ruchi, Chappell, Alfred E, Østergaard, Michael E, Swayze, Eric E, Seth, Punit P

Journal:

Nucleic Acids Research

Year:

2018

File:

PDF, 2.05 MB

2018

9

“The Schweinrich structure”, a potential site for industrial scale CO2 storage and a test case for safety assessment in Germany

Eric Kreft, Christian Bernstone, Robert Meyer, Franz May, Rob Arts, Arie Obdam, Rickard Svensson, Sara Eriksson, Pierre Durst, Irina Gaus, Bert van der Meer, Cees Geel

Journal:

International Journal of Greenhouse Gas Control

Year:

2007

Language:

english

File:

PDF, 1.04 MB

english, 2007

10

Effects of Propranolol on Phosphatidate Phosphohydrolase and Mitogen-Activated Protein Kinase Activities in A7r5 Vascular Smooth Muscle Cells

Kathryn E. Meier, Katrina C. Gause, April E. Wisehart-Johnson, Angela C.S. Gore, Eric L. Finley, Linda G. Jones, Cynthia D. Bradshaw, Anthony F. McNair, Krishna M. Ella

Journal:

Cellular Signalling

Year:

1998

Language:

english

File:

PDF, 565 KB

english, 1998

11

Antisense Oligonucleotides Containing Conformationally Constrained 2′,4′-( N -Methoxy)aminomethylene and 2′,4′-Aminooxymethylene and 2′- O ,4′- C -Aminomethylene Bridged Nucleoside Analogues Show Improved Potency in Animal Models

Prakash, Thazha P., Siwkowski, Andrew, Allerson, Charles R., Migawa, Michael T., Lee, Sam, Gaus, Hans J., Black, Chris, Seth, Punit P., Swayze, Eric E., Bhat, Balkrishen

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.75 MB

english, 2010

12

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

Seth, Punit P., Allerson, Charles R., Berdeja, Andres, Siwkowski, Andrew, Pallan, Pradeep S., Gaus, Hans, Prakash, Thazha P., Watt, Andrew T., Egli, Martin, Swayze, Eric E.

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 1.34 MB

english, 2010

13

Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides

Egli, Martin, Pallan, Pradeep S., Allerson, Charles R., Prakash, Thazha P., Berdeja, Andres, Yu, Jinghua, Lee, Sam, Watt, Andrew, Gaus, Hans, Bhat, Balkrishen, Swayze, Eric E., Seth, Punit P.

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 2.96 MB

english, 2011

14

Improving RNA Interference in Mammalian Cells by 4‘-Thio-Modified Small Interfering RNA (siRNA): Effect on siRNA Activity and Nuclease Stability When Used in Combination with 2‘- O -Alkyl Modifications

Dande, Prasad, Prakash, Thazha P., Sioufi, Namir, Gaus, Hans, Jarres, Russell, Berdeja, Andreas, Swayze, Eric E., Griffey, Richard H., Bhat, Balkrishen

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 270 KB

english, 2006

15

Configuration of the 5′-Methyl Group Modulates the Biophysical and Biological Properties of Locked Nucleic Acid (LNA) Oligonucleotides

Seth, Punit P., Allerson, Charles R., Siwkowski, Andrew, Vasquez, Guillermo, Berdeja, Andres, Migawa, Michael T., Gaus, Hans, Prakash, Thazha P., Bhat, Balkrishen, Swayze, Eric E.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.52 MB

english, 2010

16

Differential Roles of the Protein Corona in the Cellular Uptake of Nanoporous Polymer Particles by Monocyte and Macrophage Cell Lines

Yan, Yan, Gause, Katelyn T., Kamphuis, Marloes M. J., Ang, Ching-Seng, O’Brien-Simpson, Neil M., Lenzo, Jason C., Reynolds, Eric C., Nice, Edouard C., Caruso, Frank

Journal:

Year:

2013

Language:

english

File:

PDF, 4.12 MB

english, 2013

17

Physicochemical and Immunological Assessment of Engineered Pure Protein Particles with Different Redox States

Gause, Katelyn T., Yan, Yan, Cui, Jiwei, O’Brien-Simpson, Neil M., Lenzo, Jason C., Reynolds, Eric C., Caruso, Frank

Journal:

Year:

2015

Language:

english

File:

PDF, 4.23 MB

english, 2015

18

Characterizing investor expectations for assets with varying risk

Gaus, Eric, Sinha, Arunima

Journal:

Research in International Business and Finance

Year:

2016

Language:

english

File:

PDF, 1.26 MB

english, 2016

19

Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys

Shemesh, Colby S, Yu, Rosie Z, Gaus, Hans J, Greenlee, Sarah, Post, Noah, Schmidt, Karsten, Migawa, Michael T, Seth, Punit P, Zanardi, Thomas A, Prakash, Thazha P, Swayze, Eric E, Henry, Scott P, Wang

Journal:

Molecular Therapy — Nucleic Acids

Year:

2016

Language:

english

File:

PDF, 4.02 MB

english, 2016

20

Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes

Kinberger, Garth A., Prakash, Thazha P., Yu, Jinghua, Vasquez, Guillermo, Low, Audrey, Chappell, Alfred, Schmidt, Karsten, Murray, Heather M., Gaus, Hans, Swayze, Eric E., Seth, Punit P.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 475 KB

english, 2016

21

Robust Stability of Monetary Policy Rules under Adaptive Learning

Journal:

Southern Economic Journal

Year:

2013

Language:

english

File:

PDF, 254 KB

english, 2013

22

Learning and loss functions: comparing optimal and operational monetary policy rules

Gaus, Eric, Ramamurthy, Srikanth

Journal:

International Journal of Mathematical Modelling and Numerical Optimisation

Year:

2014

Language:

english

File:

PDF, 501 KB

english, 2014

23

Codelivery of NOD2 and TLR9 Ligands via Nanoengineered Protein Antigen Particles for Improving and Tuning Immune Responses

Gause, Katelyn T., Yan, Yan, O'Brien-Simpson, Neil M., Cui, Jiwei, Lenzo, Jason C., Reynolds, Eric C., Caruso, Frank

Journal:

Advanced Functional Materials

Year:

2016

Language:

english

File:

PDF, 1.03 MB

english, 2016

24

Resolving relationships at the animal-fungal divergence: A molecular phylogenetic study of the protist trichomycetes (Ichthyosporea, Eccrinida)

Reynolds, Nicole K., Smith, Matthew E., Tretter, Eric D., Gause, Justin, Heeney, Dustin, Cafaro, Matías J., Smith, James F., Novak, Stephen J., Bourland, William A., White, Merlin M.

Journal:

Molecular Phylogenetics and Evolution

Year:

2017

Language:

english

File:

PDF, 11.49 MB

english, 2017

25

Identification of metabolically stable 5΄-phosphate analogs that support single-stranded siRNA activity

Prakash, Thazha P., Lima, Walt F., Murray, Heather M., Li, Wenyu, Kinberger, Garth A., Chappell, Alfred E., Gaus, Hans, Seth, Punit P., Bhat, Balkrishen, Crooke, Stanley T., Swayze, Eric E.

Journal:

Nucleic Acids Research

Year:

2017

Language:

english

File:

PDF, 85 KB

english, 2017

26

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor

Schmidt, Karsten, Prakash, Thazha P., Donner, Aaron J., Kinberger, Garth A., Gaus, Hans J., Low, Audrey, Østergaard, Michael E., Bell, Melanie, Swayze, Eric E., Seth, Punit P.

Journal:

Nucleic Acids Research

Year:

2017

Language:

english

File:

PDF, 903 KB

english, 2017

27

Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

Prakash, Thazha P, Mullick, Adam E, Lee, Richard G, Yu, Jinghua, Yeh, Steve T, Low, Audrey, Chappell, Alfred E, Østergaard, Michael E, Murray, Sue, Gaus, Hans J, Swayze, Eric E, Seth, Punit P

Journal:

Nucleic Acids Research

Year:

2019

Language:

english

File:

PDF, 3.73 MB

english, 2019

28

Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice

Chappell, Alfred E, Gaus, Hans J, Berdeja, Andres, Gupta, Ruchi, Jo, Minji, Prakash, Thazha P, Oestergaard, Michael, Swayze, Eric E, Seth, Punit P

Journal:

Nucleic Acids Research

Year:

2020

Language:

english

File:

PDF, 2.81 MB

english, 2020

29

Targeted Delivery of Antisense Oligonucleotides Using Neurotensin Peptide

Nikan, Mehran, Tanowitz, Michael, Dwyer, Chrissa A., Jackson, Michaela, Gaus, Hans, Swayze, Eric, Rigo, Frank, Seth, Punit P, Prakash, Thazha P.

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 2.04 MB

2020

30

[Advances in Econometrics] Topics in Identification, Limited Dependent Variables, Partial Observability, Experimentation, and Flexible Modeling: Part A || A New Approach to Modeling Endogenous Gain Learning

Year:

2019

File:

PDF, 1004 KB

2019

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